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目的通过脊髓脊膜膨出修补术后应用透明质酸,观察术后症状的改善、功能的恢复,探讨其预防脊髓栓系综合征的作用。方法将31例接受脊髓脊膜膨出修补术的病例随机分成透明质酸治疗组(A组)16例及对照组(B组)15例,所有病例都经显微手术治疗,术毕A组以地塞米松5mg+透明质酸1支(1500U)+生理盐水10~15ml喷于脊髓周围及创腔内;B组用地塞米松5mg+生理盐水10~15ml局部使用。以术后症状缓解及功能恢复情况判断效果。结果术后随访8个月至3年,A组术后症状明显缓解,功能恢复程度高,优良率75%;B组优良率53%,两者差异显著(P<0.01)。结论显微手术彻底松解粘连同时局部应用透明质酸是治疗脊髓脊膜膨出修补术后预防脊髓栓系综合征的有效办法。
Objective To observe the effects of hyaluronic acid (hyaluronic acid) after the repair of spinal meningocele, to observe the improvement of postoperative symptoms and the recovery of function, and to explore its role in preventing tethered cord syndrome. Methods Thirty-one cases of spinal meningocele repair were randomly divided into 16 cases of hyaluronic acid treatment group (A group) and 15 cases of control group (B group), all cases were treated by microsurgical operation, group A Dexamethasone 5mg + 1 hyaluronic acid (1500U) + saline 10 ~ 15ml spray around the spinal cord and wound cavity; B group with dexamethasone 5mg + saline 10 ~ 15ml topical use. To postoperative symptoms and functional recovery to determine the effect of the situation. Results The patients were followed up for 8 months to 3 years. The postoperative symptoms of group A were relieved and the degree of functional recovery was high. The excellent and good rate was 75%. The excellent and good rate was 53% in group B (P <0.01). Conclusions Microsurgical lymphadenectomy is an effective and effective method for the prevention of tethered cord syndrome after complete release of adhesions and local application of hyaluronic acid.