可溶性白细胞介素６受体存在于人的尿、血清和某些细胞的体外培养上清中。肿瘤、感染和自身免疫性疾病的发生过程中ｓＩＬ－６Ｒ的水平显著升高。用基因重组ｓＩＬ－６Ｒ研究表明，ｓＩＬ－６Ｒ与ＩＬ－６结合后仍能介导ＩＬ－６的生物学功能，因此它不仅不能作为其配体ＩＬ－６的拮抗剂．反而是配体的激动剂，这点与其它细胞因子的可溶性受体绝然不同。ｓＩＬ－６Ｒ在机体的免疫调节和多种疾病的发生、发展过程中可能发挥重要作用。通过阻断ｓＩＬ－６Ｒ的生物学作用，可能为某些疾病的治疗提供新的方法。 Soluble interleukin-6 receptor is present in human urine, serum and some cells in vitro culture supernatant. The levels of sIL-6R are significantly elevated during the development of tumors, infections and autoimmune diseases. Using sIL-6R gene recombination studies showed that sIL-6R and IL-6 binding IL-6 can still mediate the biological function, it not only can not act as an antagonist of its ligand IL-6. Rather, it is a ligand agonist, which is quite different from soluble receptors of other cytokines. sIL-6R may play an important role in the body’s immune regulation and occurrence and development of various diseases. By blocking the biological role of sIL-6R, it may provide a new method for the treatment of certain diseases.