自从认识到氟在龋病预防中的重要地位之后,人们就开始了对其抗龋机理的探讨。弄清机理不仅对于提高防龋效果,而且对于最终揭开龋病病因之谜也是有意义的。早年,许多学者多注重于研究氟对牙齿发育的影响,认为在牙齿发育期间氟可以改善磷灰石的结晶性(crystatlinity),使牙齿中形成更多耐酸溶解的氟磷灰石;并且氟还能够改变牙齿的形态,使窝沟变浅等等。但是,这些理论无法解释牙齿荫出后接受氟防龋措施所获得的抗龋效果。因此,近年来,一些学者根据以往的大量实验资料提出,氟的抗龋作用主要发生在局部。从龋病发生学的角度来看,上述论点是站得住脚的。众所周知,龋病过程开始于菌斑—釉质界面。龋病的发生,除去一些其它因素之外很大程 Since the recognition of fluoride in the prevention of caries in an important position, people began to explore its anti-caries mechanism. To clarify the mechanism not only for improving the effect of caries prevention, but also for the final reveal the etiology of dental caries also makes sense. In the early years, many scholars focused more on the effects of fluoride on tooth development, believing that fluoride can improve the crystalline nature of apatite during tooth development, resulting in more acid-soluble fluorapatite in the teeth; and fluoride Can change the shape of the teeth, make the fossa shallow and so on. However, these theories can not explain the anti-caries effect of dental caries after fluoride embolism. Therefore, in recent years, some scholars based on the past a large number of experimental data suggest that fluorine anti-caries mainly occurs in the local. From the point of view of cariogenesis, the above argument is tenable. It is well-known that the carious process begins at the plaque-enamel interface. The occurrence of caries, a lot of other things aside