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目的探讨血清降钙素原(PCT)、C-反应蛋白(CRP)水平在脓毒血症诊断中的临床意义。方法选取脓毒血症患者72例(脓毒血症组)及同时间段内收治的非脓毒血症患者72例(对照组),测定两组血清PCT、CRP水平,并记录脓毒血症组21 d内预后(死亡或好转)情况。结果脓毒血症组血清PCT、CRP水平均高于对照组(P<0.01);脓毒血症组中脓毒症休克患者血清PCT、CRP水平均高于未休克脓毒症患者(P<0.01);脓毒血症组病死率为19.44%,住院21 d内死亡患者入院时血清PCT、CRP水平高于存活患者(P<0.01)。结论检测血清PCT、CRP对于脓毒血症的早期的诊断及预后均有临床指导意义。
Objective To investigate the clinical significance of serum procalcitonin (PCT) and C-reactive protein (CRP) levels in the diagnosis of sepsis. Methods Seventy-two sepsis patients (sepsis group) and 72 non-sepsis patients (control group) were enrolled in this study. Serum PCT and CRP levels were measured in both groups and sepsis Syndrome group 21 d prognosis (death or improvement) situation. Results The levels of PCT and CRP in sepsis group were significantly higher than those in control group (P <0.01). The levels of PCT and CRP in sepsis group were higher than those in sepsis group (P < 0.01). The mortality of sepsis group was 19.44%. The PCT and CRP levels of serum PCT and CRP in hospitalized patients within 21 days after hospitalization were higher than those in survivors (P <0.01). Conclusion Detecting serum PCT and CRP have clinical significance in the early diagnosis and prognosis of sepsis.