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目的:观察缬沙坦单用及与福辛普利或非洛地平合用对老年高血压的降压疗效。方法:80例老年轻、中度高血压患者,经过2周安慰剂清洗期后,单服缬沙坦80 mg,qd。4周后随机分2组,分别联合服用福辛普利10 mg,qd,或非洛地平5 mg, qd,均为4周。治疗前及治疗后4周和8周行24 h动态血压监测,并测治疗前后坐位血压。结果:缬沙坦单用4周后,坐位血压和24 h动态血压均下降(P<0．01或P<0．05)。缬沙坦与福辛普利或非洛地平合用4 wk后坐位血压总有效率从45％增加为88％和85％;动态血压显示联合用药降压作用较明显。结论:缬沙坦单用有长效的降压作用,与福辛普利或非洛地平联合用药有叠加降压作用。
Objective: To observe the antihypertensive effects of valsartan alone and in combination with fosinopril or felodipine on senile hypertension. METHODS: Eighty elderly, moderately hypertensive patients received valsartan 80 mg qd after 2 weeks of placebo washout. After 4 weeks, they were randomly divided into two groups, taking fosinopril 10 mg, qd, or felodipine 5 mg, qd respectively for 4 weeks. Before treatment and after treatment for 4 weeks and 8 weeks, 24-hour ambulatory blood pressure monitoring was performed, and blood pressure was measured before and after sitting. Results: After 4 weeks of valsartan alone, the sitting blood pressure and ambulatory blood pressure decreased 24 h (P <0.01 or P <0.05). After 4 wk of valsartan combined with fosinopril or felodipine, the total effective rate of sitting blood pressure increased from 45% to 88% and 85% respectively; ambulatory blood pressure showed the combination of antihypertensive effect was more obvious. Conclusion: Valsartan alone has a long-acting antihypertensive effect, and fosinopril or felodipine combined with antihypertensive effect.