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目的探讨胰岛素样生长因子-1与颈动脉粥样硬化的相关关系。方法依据脑动脉造影表现选取不同狭窄程度患者共65例及无狭窄者22例,狭窄组患者中轻中度各22例,重度狭窄23例,收集临床资料及实验室、颈部血管超声检查表现,采用ELISA测量患者血浆胰岛素样生长因子-1(IGF-1)水平。比较不同狭窄组IMT、IGF-1及各种心血管危险因素的水平。结果与无狭窄组比较,狭窄组患者颈动脉IMT厚度明显增加,IGF-1水平明显减低,心血管危险因素水平增高。IGF-1与IMT呈明显负相关。Logistic回归提示IGF-1作为心血管的一种保护因子。结论 IGF-1水平与颈动脉粥样硬化狭窄有关,IGF-1作为血管的一种保护因子,可作为一种提示脑血管状况的指标。
Objective To investigate the relationship between insulin-like growth factor-1 and carotid atherosclerosis. Methods According to cerebral arteriography, 65 patients with different degree of stenosis and 22 patients without stenosis were selected. In the stenosis group, there were 22 patients with mild to moderate degree and 23 patients with severe stenosis. The clinical data and the results of ultrasonography The plasma level of insulin-like growth factor-1 (IGF-1) was measured by ELISA. The levels of IMT, IGF-1 and various cardiovascular risk factors in different stenosis groups were compared. Results Compared with the non-stenosis group, carotid IMT thickness was significantly increased in the stenosis group, IGF-1 level was significantly decreased, and cardiovascular risk factors were increased. IGF-1 and IMT showed a significant negative correlation. Logistic regression suggested that IGF-1 acts as a cardiovascular protective factor. Conclusion The level of IGF-1 is related to the stenosis of carotid atherosclerosis. IGF-1 is a protective factor of blood vessel, which can be used as an indicator of cerebral vascular status.