论文部分内容阅读
瑞典药物不良反应顾问委员会将1972～1984年期间国内与复方新诺明有关的副作用的报告进行了分析,以便对副作用类型及发生率进行评价。 在这12早期间共收到1234个报告,报道1721项可能同复方新诺明治疗有关的副作用,最常见的为皮肤反应(878),发烧(264),胃肠道障碍(224)及血/骨髓反应(192)。约20％副作用极严重,最多见的是皮肤和粘膜过敏反应,肝和骨髓的过敏反应或特异反应。 只有48名(40％)患者<51岁,而有432(36％)名患者≥70岁。在70岁以上的患者中多发生全细胞贫血,粒细胞缺乏症,血小板减少
The Swedish Adverse Drug Reaction Advisory Board analyzed domestic reports of side effects associated with cotrimoxef from 1972 to 1984 for the purpose of evaluating the types and incidence of side effects. A total of 1234 reports were received during these 12 early-morning periods and reported 1721 possible side effects associated with cotrimoxazole, the most common being skin reactions (878), fever (264), gastrointestinal disorders (224) and blood / Bone marrow response (192). About 20% of the serious side effects, the most common are skin and mucosal anaphylaxis, liver and bone marrow allergic reactions or specific reactions. Only 48 (40%) patients <51 years and 432 (36%) patients ≥70 years. More than 70 years of age in patients with multiple cell anemia, agranulocytosis, thrombocytopenia