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微核不见于正常人。现在有报导,一般受电离辐射或化学诱变因子等处理过的动植物敏感细胞都能出现微核。我们观察到,微核亦出现于肝癌患者的淋巴细胞;在对肝癌患者及非癌肝病忠者微核出现率进行的比较中发现:非癌肝病患者中已有微核出现,出现率均数为4.8‰,而肝癌患者中,其微核率较高,均数为23.9‰。据此,微核测定法在辅助诊断肝癌方面可能有一定的参考价值。
Micronucleus is not seen in normal people. It has been reported that micro-nuclei can be found in sensitive cells of plants and animals that have been treated with ionizing radiation or chemical mutagenic factors. We observed that micronuclei also appeared in lymphocytes of patients with liver cancer; in the comparison of the frequency of micronuclei in patients with hepatocellular carcinoma and non-cancerous liver disease, it was found that micronuclei were present in patients with non-cancerous liver disease, and the average rate of occurrence was observed. It was 4.8 ‰, while the liver cancer patients had a high micronucleus rate of 23.9 均. Accordingly, micronucleus assay may have certain reference value in assisting diagnosis of liver cancer.