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目的 探讨酮咯酸的局部镇痛作用。方法 动物实验采用兔齿髓刺激法和小鼠福尔马林实验 ,临床疼痛评定采用视觉模拟评分法。结果 齿髓内注射酮咯酸氨丁三醇(KT) 15 0 μg/kg·只 -1能显著提高兔齿髓电刺激的痛阈而静注无效 ;小鼠左上唇scKT 1 6mg·kg-1能明显抑制该部位sc福尔马林的疼痛反应 ,但对对侧 (右上唇 )sc福尔马林所致的疼痛反应无效。临床小剂量KT口腔患处敷极显著降低患者的疼痛分值。结论 酮咯酸具有局部镇痛作用 ,可用于口腔疼痛的治疗
Objective To investigate the analgesic effect of ketorolac. Methods Animal experiments using rabbit pulp stimulation and formalin test in mice, clinical pain assessment using visual analog scale method. Results Intra-ketoterone injection of ketorolac tromethamine (KT) at a dose of 15 μg / kg · kg-1 could significantly increase the pain threshold of electrical stimulation of the rabbit’s spinal cord without intravenous injection. The scKT of the left upper lip of the mice was 16 mg · kg- 1 significantly inhibited the response to sc-formalin in this area, but did not respond to the pain response caused by contralateral (right-sided) sc-formalin. Clinical small doses of KT oral lesions significantly reduce the patient’s pain score. Conclusions Ketorolac has a local analgesic effect and can be used for the treatment of oral pain