吸烟及尼古丁成瘾与肺癌发病关系密切;但尼古丁及其致癌衍生物的作用机理尚未阐明。最近发现,不同组织类型肺癌细胞株的胞膜上均能表达高亲和性的μ、δ和κ阿片受体、左旋尼古丁受体,以及α-环蛇毒素受体。这些受体的数目等于甚至多于它们在哺乳动物脑中所表达的数量。给予尼古丁 Smoking and nicotine addiction is closely related to the incidence of lung cancer; however, the mechanism of action of nicotine and its carcinogenic derivatives has not been elucidated yet. Recently, it was found that high affinity mu, delta and kappa opioid receptors, levorotatory nicotine receptors, and a-bungarotoxin receptors were expressed on the membrane of lung cancer cell lines of different tissue types. The number of these receptors equals or exceeds even the amount they express in the mammalian brain. Give nicotine