Large-scale Cenozoic magmatic rocks from the interplay between the Indian and Eurasian plate are exposed in the Yulong porphyry copper belt in the northern Jinshajiang-Ailaoshan domain. Alkali-rich magmas along the Yulong porphyry copper belt can reveal the tectono-magmatic processes in the Sanjiang region. In this study, we present new zircon U-Pb-Hf isotopes and whole rock geochemistry of Cenozoic granitoids from the Zhalaga area in the northern Yulong porphyry copper belt. The Zircon U-Pb dating results show that the Zhalaga granitic porphyry crystallized at ca. 42-38 Ma. These porphyry deposits are depleted in Nb, Ta, Sr, and Ti enriched in alkaline and rare earth elements (REEs), and exhibit high zircon saturation temperatures, that strongly indicate A-type affinity. These data and the generally positive εHf(t) values (2.0-4.5) suggest the magmas originated from a hybrid of partial melting of subduction-modified lithospheric mantle, possibly triggered by upwelling of the asthenospheric mantle. Geochronological and geochemical data of the current and previous studies distinguish three magmatic phases during the Cenozoic in the Jinshajiang-Ailaoshan region: (1) ca. 62-48 Ma; (2) ca. 44-30 Ma; and (3) ca. 28-16 Ma. The strong collision between the Indian and Eurasian plates produced relatively fast convergence rates during the first episode (ca. 62-48 Ma), whereas the subsequent right-lateral strike-slip faulting in the Jinshajiang fault zone initiated at ca. 43 Ma is associated with the relatively low India-Eurasia convergence rates during ca. 44-30 Ma. These significantly impacted the nature and spatial distribution of the magmatism and the large-scale metallogeny during the Cenozoic in the Sanjiang region. We suggest that the Zhalaga alkali-rich magmas occurred in a transition period from involving soft to hard collisional settings. This remarkable example demonstrates that alkali-rich magmas with A-type affinity are also generated in an orogenic tectonic setting.