神经管畸形(NTDs)是由于胚胎发育过程中,神经管闭合不全而引起的一组出生缺陷,也是临床常见的出生缺陷之一。主要包括无脑畸形、脊柱裂、脑积水、脑或脑脊膜膨出等。NTDs可造成妊娠期妇女流产及围生儿和婴儿病死或终身残疾,给社会和家庭造成沉重负担,因此深入研究NTDs临床特点并进行有效预 Neural tube defects (NTDs) are a group of birth defects caused by incomplete neural tube during embryonic development and are also one of the common clinical birth defects. Including anencephaly, spina bifida, hydrocephalus, brain or meningeal bulging and so on. NTDs can cause miscarriage of pregnant women and the death or permanent disability of infants and infants, posing a heavy burden on society and families. Therefore, the in-depth study on the clinical features of NTDs and their effective pre-treatment