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目的应用64排螺旋CT测量肝脏体积,探讨原发性胆汁性肝硬化(PBC)失代偿期患者肝脏体积变化的特点。方法搜集PBC住院患者48例作为PBC组,同期搜集乙型肝炎病毒相关肝硬化患者64例作为HBC组,并随机选取同期52例正常人作为对照组,所有病例均行腹部CT增强扫描,将门静脉期图像分解后所获得的轴面图像数据传输至GE Advantage Workstation 4.4,重建并计算出肝脏体积,计算出标准化的肝脏体积后,应用SPSS15.0统计软件,对三组肝体积均数的总体差异和两两组间差异进行比较。结果 (1)比较PBC组、HBC组、对照组的CT测量肝脏体积和标准化肝体积的差异均有统计学意义(F=7.435,P=0.024;F=4.862,P=0.012);(2)分别比较两两组间CT测量肝脏体积和标准化肝体积的差异,其中PBC组与HBC组之间、HBC组与对照组之间的差异均有统计学意义(P<0.05),PBC组与对照组的差异均无统计学意义(P>0.050)。结论 PBC倾向好发于女性,失代偿期肝脏体积缩小不显著,部分仍呈弥漫性增大。
Objective To measure the volume of liver using 64-slice spiral CT and investigate the change of liver volume in patients with decompensated primary biliary cirrhosis (PBC). Methods Forty-eight inpatients with PBC were collected as PBC group. Sixty-four HCC patients with hepatocirrhosis-related cirrhosis were collected during the same period. Fifty-two normal subjects were selected as control group. All patients underwent abdominal CT enhanced scanning. The axial image data obtained after phase image decomposition was transmitted to GE Advantage Workstation 4.4 to reconstruct and calculate the liver volume. After calculating the normalized liver volume, the SPSS15.0 statistical software was used to calculate the total difference of the three groups’ liver volume mean Differences between groups were compared. Results (1) There was significant difference between CT volume and CT volume in PBC group, HBC group and control group (F = 7.435, P = 0.024; F = 4.862, P = 0.012) The differences of liver volume and normalized liver volume between two groups were compared respectively. The difference between PBC group and HBC group and between HBC group and control group were statistically significant (P <0.05), PBC group and control group There was no significant difference between groups (P> 0.050). Conclusions PBC tended to predispose women, and the decompensated liver volume did not decrease significantly, and some still showed diffuse increase.