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目的 观察慢性肾小球肾炎患者血清甲状腺激素水平的变化及其临床意义。方法 采用放射免疫法检测 183例慢性肾小球肾炎患者治疗前后甲状腺激素水平 ,并与正常人对照。结果 患者治疗前及治疗后病情无好转时 ,其T3 明显低于对照组 (P <0 .0 1) ,而T4及TSH无显著改变 (P >0 .0 5 ) ;当治疗后病情明显好转或达到完全缓解时T3 值接近正常 ,T4及TSH也无明显改变 (P >0 .0 5 )。这种不伴TSH升高的低T3 情况考虑为病态甲状腺综合征中的低T3 综合征 ,与疾病分期有关 ,并与Karnofsky健康状态有关。结论 动态监测患者血清甲状腺激素水平 ,可以作为观察患者病情、判断疗效及评估预后的有效指标。
Objective To observe the changes of serum thyroid hormones in patients with chronic glomerulonephritis and its clinical significance. Methods The levels of thyroid hormone in 183 patients with chronic glomerulonephritis before and after treatment were detected by radioimmunoassay and compared with normal controls. Results Before treatment and after treatment, the patients’ T3 was significantly lower than that of the control group (P <0.01), but there was no significant change of T4 and TSH (P> 0.05). After the treatment, the condition was obviously improved The T3 value approached normal when complete remission was achieved, and there was no significant change in T4 and TSH (P> 0.05). This low-T3 condition without elevated TSH is considered as a low-T3 syndrome in the pathological thyroid syndrome and is related to the stage of the disease and to the state of Karnofsky’s health. Conclusion The dynamic monitoring of thyroid hormone levels in patients can be used as an effective indicator to observe the patient’s condition, to determine the efficacy and prognosis.