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目的 :探讨华法林钠片治疗慢性心房颤动(AF)合并脑栓塞患者的疗效。方法 :将我院2012年6月~2013年6月收治的98例AF合并脑栓塞患者按照1∶1比例随机分为两组,每组各49例,对照组单纯氯吡格雷治疗,观察组给予华法林治疗,并对两组患者相关指标进行统计学分析。结果 :观察组总有效率97.96%明显高于对照组总有效率77.55%;治疗后2周开始患者SSS逐渐降低,Barthel逐渐升高,治疗后2周、4周观察组患者SSS评分优于对照组,治疗后8周和12周两组SSS评分差异无统计学意义;治疗后,两组患者凝血功能各项指标均有所升高;但在变化趋势上,观察组变化幅度显著优于对照组。结论 :华法林治疗房颤合并脑栓塞病人疗效确切,有利于患者神经功能缺损、日常生活活动能力及凝血功能的恢复,且安全性高,值得临床广泛推广和应用。
Objective: To investigate the curative effect of warfarin sodium tablets in patients with chronic atrial fibrillation (AF) complicated with cerebral embolism. Methods: A total of 98 patients with AF complicated with cerebral embolism admitted from June 2012 to June 2013 in our hospital were randomly divided into two groups according to the ratio of 1: 1, with 49 patients in each group. The control group was treated with clopidogrel only. The observation group Give warfarin treatment, and statistical analysis of the two groups of patients related indicators. Results: The total effective rate in the observation group was 97.96%, which was significantly higher than that in the control group (77.55%). SSS decreased gradually and Barthel gradually increased from the second week after treatment. The SSS score of the observation group was superior to the control There was no significant difference in SSS score between the two groups after 8 weeks and 12 weeks of treatment. After treatment, the indexes of coagulation function increased in both groups. However, in the changing trend, the changes in observation group were significantly better than those in control group group. CONCLUSION: Warfarin is effective in treating atrial fibrillation complicated with cerebral embolism. It is good for patients with neurological deficits, activities of daily living and recovery of coagulation function. It is safe and worthy of wide application in clinic.