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目的:探讨TSLC1和MPP3两种蛋白在胰腺癌中的表达和临床病理意义.方法:采用免疫组织化学S-P法检测37例胰腺癌组织、12例胰腺炎组织和10例正常胰腺组织中TSLC1和MPP3两种蛋白的表达.结果:TSLC1、MPP3蛋白在胰腺癌组织中的阳性表达率均明显低于在正常胰腺组织和胰腺炎组织中的表达(21.62%vs70.00%,75.00%;27.03%vs80.00%,66.67%,P<0.05或0.01).TSLC1和MPP3蛋白的异常表达均与胰腺癌的分化程度、淋巴结转移和TNM分期相关(均P<0.05),而与患者的性别、年龄、部位和病理分型无关.在37例胰腺癌中TSLC1与MPP3蛋白表达呈显著正相关(rs=0.715,P<0.01).结论:胰腺癌中存在TSLC1和MPP3基因的失活和蛋白表达下调,两者可能通过TSLC1-MPP3级联反应共同参与胰腺癌的发生、发展和转移.
Objective: To investigate the expression and clinicopathological significance of TSLC1 and MPP3 proteins in pancreatic cancer.Methods: Immunohistochemical SP method was used to detect TSLC1 and MPP3 in 37 cases of pancreatic cancer, 12 cases of pancreatitis and 10 cases of normal pancreas Results: The positive rates of TSLC1 and MPP3 protein in pancreatic cancer tissues were significantly lower than those in normal pancreatic tissues and pancreatic tissues (21.62% vs70.00%, 75.00%, 27.03% vs80 (P <0.05). The abnormal expression of TSLC1 and MPP3 protein was correlated with the degree of differentiation, lymph node metastasis and TNM staging of pancreatic cancer (all P <0.05), but not with the gender, age, TSLC1 and MPP3 protein expression in 37 cases of pancreatic cancer was positively correlated (rs = 0.715, P <0.01) .Conclusion: TSLC1 and MPP3 gene in pancreatic cancer inactivation and protein expression downregulation, Both of them may participate in the occurrence, development and metastasis of pancreatic cancer through the TSLC1-MPP3 cascade reaction.