经皮冠状动脉成形术(PTCA)已是目前冠脉再通的有效方法之一,但被扩张的冠状动脉段术后再狭窄的发生率却高达30％～50％,严重影响了PTCA术的远期效果。 再狭窄多发生在术后3～6个月,如术后6个月不发生再狭窄,此后就很少发生。其发生率之所以居高不下,主要是目前对再狭窄的发生机理还不十分清楚。经研究认为,PTCA术后再狭窄本是机体对球囊扩张造成血管损伤的一种修复反应,过度增生可引起内膜增厚而发生再狭窄。可能的机理 Percutaneous transluminal coronary angioplasty (PTCA) is one of the effective methods for recanalization of coronary arteries. However, the rate of restenosis after coronary artery stenosis is as high as 30% -50% Long-term effect. Restenosis occurred in 3 to 6 months after surgery, such as no restenosis after 6 months, since then rarely occur. The reason why the high rate of occurrence, mainly the current mechanism of restenosis is not yet clear. The study suggests that, after PTCA restenosis is the body of the balloon dilated vascular injury caused by a repair reaction, hyperplasia can cause intimal thickening and restenosis. Possible mechanism