经外周静脉穿刺置入中心静脉导管(peripherally inserted central catheters,PICC)在临床已广泛应用,导管断裂是最严重的并发症,导管断裂的发生率为0.1%~3.5%~([1])。纤维蛋白鞘相关性导管功能障碍是PICC长期留置过程中最常见的远期并发症之一,如导管阻塞、渗液、导管失去功能而更换导管、导管相关性血栓形成~([2])。导管性纤维蛋白鞘形成导致拔管困难的病例未见报道。现将我院1例纤维蛋白鞘形成致拔管困难导管断 Peripheral venous catheterization peripherally inserted central catheters (PICC) has been widely used in clinical practice, and catheter rupture is the most serious complication. The incidence of catheter rupture is 0.1% ~ 3.5% ~ ([1]). Fibrin sheath-related catheter dysfunction is one of the most common long-term complications of long-term PICC placement, such as catheter blockage, exudation, catheter loss of function, and catheter-dependent thrombosis (2). No cases of ductal fibrin sheath formation leading to extubation have been reported. A case of fibrin sheath in our hospital now leads to difficult catheter extubation