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目的探讨磁性微粒(Fe3O4)经动脉导管栓塞肿瘤机理与临床应用。方法采用Seld inger技术插管,用Fe3O4+5-Fu混悬药液栓塞94例肿瘤患者,其中5例肝癌栓塞后靶区外置磁场,15例栓后手术切除标本HE染色制片,25例栓塞1月后DSA复查,前后图像对照作统计学处理。结果病理提示肿瘤组织坏死彻底,栓塞前后DSA图像定量分析P值<0.05,临床观察栓后综合征明显下降。结论Fe3O4微粒是一种永久性栓塞颗粒,具有缓慢栓塞作用,对减少栓后临床并发症有一定作用。
Objective To investigate the mechanism and clinical application of magnetic particles (Fe3O4) embolized by arterial catheter. Methods Seldinger technique was used to intubate the tumor in 94 patients with Fe3O4 + 5-Fu suspension. Five of them were exposed to external magnetic fields after the embolization of the liver tumor. Fifteen patients underwent surgical resection with HE staining and 25 patients DSA after embolization in January review, before and after the image control for statistical analysis. Results The pathological findings of complete necrosis of tumor tissue before and after embolization DSA quantitative analysis of P values <0.05, the clinical observation of post-suppository syndrome decreased significantly. Conclusion Fe3O4 particles are a kind of permanent embolic particles with a slow embolization effect, which can reduce the clinical complications after the suppository.