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炎症在急性冠状动脉综合征(ACS)形成过程中起关键作用,与心血管疾病的发生、发展、病理生理变化、诊断、治疗和预后密切相关。炎症标志物(1)C反应蛋白(CRP),(2)白介素(IL),(3)CD40-CD40L系统,(4)髓过氧化物酶(MPO),(5)妊娠相关性血浆蛋白A(PAPP-A),(6)核因子κB(NF-κB)在ACS的演变过程中起重要作用。其病理生理基础是冠状动脉粥样斑块不稳定,发生破裂继之血栓形成,部分或完全堵塞病变的血管,从而导致不同程度的心肌缺血、损伤,发生一系列冠脉病变,ACS与炎症标志物的促发,介导相关联。本文就ACS炎症标志物的研究进展及临床意义作一综述。
Inflammation plays a key role in the formation of acute coronary syndrome (ACS) and is closely related to the occurrence, development, pathophysiological changes, diagnosis, treatment and prognosis of cardiovascular diseases. Inflammatory markers (1) C-reactive protein (CRP), (2) interleukin (IL), (3) CD40- CD40L system, (4) myeloperoxidase (MPO), (5) pregnancy associated plasma protein A (PAPP-A), (6) Nuclear factor κB (NF-κB) plays an important role in the evolution of ACS. Its pathophysiology is unstable coronary plaque, rupture followed by thrombosis, partial or complete occlusion of diseased vessels, resulting in varying degrees of myocardial ischemia and injury, a series of coronary lesions, ACS and inflammation Marker of the trigger, mediated by the association. This article summarizes the research progress and clinical significance of ACS inflammatory markers.