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目的探讨Cobas~4800高危型HPV检测技术对宫颈癌筛查的效能及与第二代杂交捕获法(HC2)的符合率。方法回顾性分析100例患者同时用Cobas~4800高危型HPV检测技术和HC2进行HPV检测的数据,并结合病理检查结果进行整理分析。结果以病理检查宫颈上皮内瘤变2及以上为宫颈癌阳性诊断标准,Cobas~4800检测技术的灵敏度为90.0%(9/10),特异度为58.9%(53/90),约登指数为48.9%,阳性预测值为19.6%(9/46),阴性预测值为98.1%(53/54)。Cobas~4800与HC2的总符合率为83.0%(χ~2=2.12,P>0.05)。结论 Cobas~4800高危型HPV检测技术对宫颈癌的筛查有较高的应用价值。
Objective To investigate the efficacy of Cobas ~ 4800 high-risk HPV testing in cervical cancer screening and its coincidence with the second generation hybridization capture method (HC2). Methods A retrospective analysis of 100 patients with both Cobas ~ 4800 high-risk HPV detection technology and HC2 for HPV testing data, combined with the results of pathological examination were analyzed. Results The pathological examination of cervical intraepithelial neoplasia 2 and above was the positive diagnostic criteria of cervical cancer. The sensitivity of Cobas ~ 4800 detection technique was 90.0% (9/10), specificity was 58.9% (53/90), the Youden index 48.9%, the positive predictive value was 19.6% (9/46), and the negative predictive value was 98.1% (53/54). The overall coincidence rate of Cobas ~ 4800 with HC2 was 83.0% (χ ~ 2 = 2.12, P> 0.05). Conclusion Cobas ~ 4800 high-risk HPV detection technology for cervical cancer screening has a higher value.