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从胰脏提取胰岛素和胰高糖素的过程中,偶然地发现了胰多肽(pancreatie polypeptide,PP)。先是Kansas大学Kimmel医师在1968年的联合生命科学年会简报上报道了鸡胰多肽(avian PP)的不完全的部分化学组成。与此同时,本研究室Chance博士等从牛、猪胰脏中发现类似的多肽,而且得到它们全部的化学组成和氨基酸序列。随着牛、猪胰多肽的发现,本研究室又从人、狗、羊的胰脏提纯同类的多肽。胰多肽含有36个直线排列的氨基酸,牛、羊、猪、人的胰多肽在36个氨基酸中,只有一、二个氨基酸的差别。猪和狗的胰多肽完全相同。牛和鸡的胰多肽,在36个氨基酸序列中,只有15个完全同位(表1,2)。从演化的观点看来,低级动物和人的胰多肽有密切的关系。
During the extraction of insulin and glucagon from the pancreas, pancreatic polypeptide (PP) was found by chance. First, Dr. Kimmel of the University of Kansas reported an incomplete partial chemical composition of avian PP at the 1968 Joint Life Science Annual Brief. In the meantime, Dr. Chance et al. Found similar peptides from bovine and porcine pancreas and obtained their complete chemical composition and amino acid sequence. With the discovery of bovine and porcine pancreatic polypeptide, our laboratory purified the same kind of polypeptide from human, dog and goat’s pancreas. Pancreatic polypeptide contains 36 linear amino acids, cattle, sheep, pigs, human pancreatic polypeptide in 36 amino acids, only one or two amino acid differences. Pig and dog’s pancreatic polypeptide exactly the same. Pancreatic peptides from cattle and chickens have only 15 of the 36 amino acid sequences completely identical (Table 1, 2). From the evolutionary point of view, lower animals and human pancreatic polypeptide are closely related.