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目的 :探讨老年血管性痴呆 ( VD)、脑血管疾病的发病与血液流变性的关系。方法 :观察老年血管性痴呆 ( VD)患者 45例、脑血管病患者 3 5例的血液流变性状况 ,对其结果比较并进行统计学分析 ,同时 ,对 VD不同智力障碍程度的血液流变性结果比较分析。结果 :血管性痴呆及其不同程度的级别与脑血管对照组比较 ,全血粘度值在高切值 ( 15 0 s- 1 )明显高于脑血管病组 ( P均 <0 .0 5 ) ;血浆粘度值又明显低于脑血管病组 ( P<0 .0 5～ 0 .0 1) ;VD患者红细胞最大变形指数显著低于脑血管病组 ( P<0 .0 5 )。结论 :血液流变性变化对于老年血管性痴呆的诊治不失为有用的临床参考指标 ,红细胞的老年性改变参与了老年血管性痴呆的发生。
Objective: To investigate the relationship between senile vascular dementia (VD) and cerebrovascular disease and hemorrheology. Methods: The hemorrheological status of 45 patients with senile vascular dementia (VD) and 35 patients with cerebrovascular disease was observed. The results were compared and statistically analyzed. At the same time, the hemorheological results of VD with different mental retardation comparative analysis. Results: Vascular dementia and its different levels were significantly higher than those of cerebrovascular control group (P <0.05). The values of whole blood viscosity at 15 0 s-1 were significantly higher than that of cerebrovascular disease group (all P <0.05). The plasma viscosity was significantly lower than that of cerebrovascular disease group (P <0.05-0.01). The maximum erythrocyte deformation index of VD patients was significantly lower than that of cerebrovascular disease group (P <0.05). Conclusion: The change of hemorheology is a useful clinical reference for the diagnosis and treatment of senile vascular dementia. Senile changes of erythrocytes are involved in the pathogenesis of senile vascular dementia.