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目的 研究肝血窦内皮细胞(SEC) 缺血再灌注损伤机理及防护方法。方法 采用大鼠肝部分热缺血再灌注模型,并用丹参和异搏定作为实验组,观察缺血45 min 及再灌注30 min 后SEC 超微结构的变化,及其与氧自由基(OFR) 和钙离子拮抗剂的关系,并测定血清谷丙转氨酶(ALT) ,谷草转氨酶(AST) 值。结果 缺血再灌注后SEC 有损伤,但与OFR和细胞内钙超载无关;丹参可防护其损伤,而异搏定不能,但二者均可使肝功能损害减轻。结论 OFR 和细胞内钙超载不是SEC 缺血再灌注损伤的原因;丹参可防护SEC 及肝细胞的缺血再灌注损伤;异搏定不能防护SEC 缺血再灌注损伤,但可防护肝细胞损伤,保护肝功能。
Objective To study the mechanism and protection of ischemia-reperfusion injury in hepatic sinusoid endothelial cells (SEC). Methods The rat model of partial hepatic ischemia / reperfusion was established. The ultrastructure of SEC was observed at 45 min after ischemia and 30 min after reperfusion with Salvia miltiorrhiza and verapamil as experimental groups, And calcium antagonists, and measured serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) value. Results SEC was injured after ischemia-reperfusion, but had no correlation with OFR and intracellular calcium overload. Salvia miltiorrhiza could prevent its injury, while Verapamil did not, but both could reduce the damage of liver function. Conclusion OFR and intracellular calcium overload is not the cause of SEC ischemia-reperfusion injury; Salvia can prevent SEC and hepatocyte ischemia-reperfusion injury; Verapamil can not protect SEC ischemia-reperfusion injury, but can protect liver cell injury, Protect liver function.