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采用酶联免疫（ＥＬＩＳＡ）法检测１００例正常人及７９例成人原发性肾病综合征（ＰＮＳ）治疗前后尿视黄醇结合蛋白（ＲＢＰ）的变化。追踪随访２年，发现经治疗后病理类型为ＥＣＰＧＮ、ＭＣＮ、ＩｇＡＧＮ者，尿蛋白及ＲＢＰ均明显减少，其肾功能不全的发生率较低，而ＭＧＮ、ＦＳＧＳ、ＳＧＮ者，尿蛋白及ＲＢＰ无明显减少，肾功能不全的发生率较高，ＭｓＰＧＮ因其增生程度的不同，治疗效果及预后有所不同，轻度增生者治疗效果及预后较好，中、重度增生者，其治疗效果及预后较差。结果表明：尿ＲＢＰ持续性增高的肾病综合征患者，肾功能不全的发生率明显高于一过性尿ＲＢＰ增高的患者（Ｐ＜０．００１）。
The changes of urinary retinol binding protein (RBP) in 100 normal subjects and 79 adults with primary nephrotic syndrome (PNS) before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA). Follow up for 2 years and found that the pathological type of ECPGN, MCN, IgAGN pathological changes were significantly reduced urinary protein and RBP, the incidence of renal insufficiency was low, and MGN, FSGS, SGN, urinary protein and RBP Significantly reduced, the incidence of renal insufficiency higher, MsPGN due to their different degrees of proliferation, treatment and prognosis are different, mild hyperplasia treatment and prognosis is good, moderate and severe proliferative, the treatment and prognosis Poor. The results showed that the incidence of renal insufficiency was significantly higher in patients with nephrotic syndrome with persistent urinary RBP than in patients with elevated urinary RBP (P <0.001).