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ＴＨ－蛋白是结石基质中的主要功能成分，在体外仿生态溶石器内对其溶解情况进行了观察。结果表明，结石中的ＴＨ－蛋白单位面积释放量为３１．２４３ｎｇ／ｍｍ￣２，速度为０．５２ｎｇ／ｍｍ￣２·ｍｉｎ；草酸钙结石基质含量较多，单位面积释放量为４０．８７９±４．５ｎｇ／ｍｍ￣２，速度为０．６８ｌｎｇ／ｍｍ￣２·ｍｉｎ；磷酸钙为２５．０３７±３．１５ｎｇ／ｍｍ￣２和０．４１７ｎｇ／ｍｍ￣２·ｍｉｎ；晶体溶解剂可加速ＴＨ－蛋白溶解，尤以ＥＤ－ＴＡ作用更明显，温度、流体速度可加速ＴＨ－蛋白解离。作者认为通过基质溶解可加速结石的溶解速度。
TH-protein is the main functional component in the stone matrix, and its dissolution was observed in the in vitro biomimetic limestone. The results showed that the amount of TH-protein released per unit area was 31.243ng / mm ~ 2 and the rate was 0.52ng / mm ~ 2 · min. The content of matrix of calcium oxalate stone was more, and the release per unit area was 40.879 ± 4.5ng / mm ~ 2, the speed of 0.68lng / mm ~ 2 · min; calcium phosphate 25.037 ± 3.15ng / mm ~ 2 and 0.417ng / mm ~ 2 · min; Acceleration of TH-protein lysis, especially in the ED-TA effect is more obvious, temperature, fluid speed can accelerate the TH-protein dissociation. The authors believe that dissolution of the matrix accelerates the rate of stone dissolution.