一般认为,丙型肝炎病毒(HCV)基因组3’端是以3’非翻译区(3’VTR)和一个polyA或C尾结尾的。HCV 3’VTR长度仅为27～63bp,估计其在HCV复制中作用不大。作者报告了HCV基因组3’端结构的新发现。通过提取HCV Ⅱ/1b型感染黑猩猩肝组织中的RNA,以互补于HCV负链RNA3’端的引物逆转录得到HCV单股正链 It is generally accepted that the 3 ’end of the Hepatitis C virus (HCV) genome ends with a 3’ untranslated region (3’VTR) and a polyA or C-tail. HCV 3’VTR is only 27-63 bp in length and is estimated to have little effect on HCV replication. The authors report a new finding of the 3 ’end structure of the HCV genome. By extracting RNA from HCV Ⅱ / 1b infected chimpanzee liver, HCV single strand positive strand was reverse transcribed with primers complementary to the 3 ’end of HCV negative strand RNA