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作者对在1983～1995年单纯全脑照射的108例脑转移中336个可测量的脑转移瘤,根据肿瘤体积、坏死范围、原发灶病理组织学和放疗后随诊期这四项进行分析,所有参数经单及多变量检验与最佳局部疗效及肿瘤无进展生存的相关性。年龄23～81岁,中位61岁;卡氏评分20～100,中位值70;43％有颅外转移;原发灶未获控制者占58％。原发瘤的前三位是肺癌(69.9％)、乳腺癌(13.7％)和黑色素瘤(5.1％);病理组织学(因预后不同,将乳腺癌
The authors analysed 336 measurable brain metastases in 108 cases of brain metastases that were irradiated with pure whole brain from 1983 to 1995. The tumor volume, necrosis range, primary histopathology, and follow-up after radiotherapy were analyzed. All parameters were correlated with optimal local efficacy and progression-free survival of tumors by single and multivariate tests. Between the ages of 23 and 81 years old, the median age was 61 years; the Karnofsky score was between 20 and 100, and the median value was 70; 43% had extracranial metastases; 58% of the primary lesions were uncontrolled. The top three primary tumors were lung cancer (69.9%), breast cancer (13.7%) and melanoma (5.1%); histopathology (due to different prognosis, the breast cancer