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目的探讨遗传性血色素沉着病蛋白(Hemochromatosis,HFE)基因多态性与中国汉族人群丙型肝炎病程进展的关联。方法应用Taq Man探针方法检测262例无症状携带者和253例进展性肝炎组rs2071303和rs9366637位点基因型,比较不同基因型与与丙型肝炎病程进展相关性。结果采用多因素logistic回归分析,结果显示rs2071303位点突变基因型AA可以增加丙型肝炎进一步进展的风险(调整OR=1.78,95%CI:1.08-2.92);单倍型分析显示,与GC单倍型相比,携带AC单倍型的个体可增加丙型肝炎进一步进展的风险;(调整OR=2.86,95%CI:1.58-5.58)。结论HFE基因多态性与中国汉族人群丙型肝炎病程进展存在关联。
Objective To investigate the association of genetic polymorphism of Hemochromatosis (HFE) gene with the progression of hepatitis C in Chinese Han population. Methods TaqMan probe was used to detect rs2071303 and rs9366637 genotypes in 262 asymptomatic carriers and 253 patients with progressive hepatitis, and the correlation between different genotypes and progression of hepatitis C were compared. The results of multivariate logistic regression analysis showed that rs2071303 mutation genotype AA could increase the risk of further progression of hepatitis C (adjusted OR = 1.78,95% CI: 1.08-2.92); haplotype analysis showed that with GC Individuals carrying AC haplotypes increased the risk of further progression of hepatitis C compared to the haplotypes (adjusted OR = 2.86, 95% CI: 1.58-5.58). Conclusions HFE gene polymorphism is associated with the progression of hepatitis C in Chinese Han population.