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目的：探讨地塞米松（Ｄｅｘ） 对内毒素肺损伤的治疗机制，观察其对体内神经肽含量变化的影响。方法：制作绵羊慢性肺淋巴瘘模型，应用大肠杆菌内毒素静脉滴入导致急性肺损伤并使用大剂量Ｄｅｘ 防治，利用放免方法测定血浆、肺淋巴液神经肽含量及血浆皮质醇（ＣＳ） 含量变化。结果：内毒素致伤后血浆、肺淋巴液中血管活性肠肽（ ＶＩＰ） 和Ｐ 物质（ＳＰ） 含量及血浆ＣＳ 含量明显升高，大剂量Ｄｅｘ 可明显抑制这一变化。结论：大剂量Ｄｅｘ 对抗内毒素所致肺损伤的作用可能部分是通过调节体内神经肽及ＣＳ 含量来实现的
Objective: To investigate the therapeutic mechanism of dexamethasone (Dex) on endotoxin-induced lung injury and to observe its effect on the content of neuropeptides in vivo. Methods: A chronic lung lymphatic fistula model was made in sheep. The acute lung injury caused by intravenous infusion of E. coli endotoxin was induced by high dose Dex and the content of neuropeptide in plasma and pulmonary lymphocyte and the content of plasma cortisol (CS) were determined by radioimmunoassay . Results: The level of vasoactive intestinal peptide (VIP) and substance P (SP) and the content of plasma CS in plasma and pulmonary lymph fluid were significantly increased after endotoxin-induced injury. The high dose Dex significantly inhibited this change. CONCLUSIONS: The effect of high-dose Dex against endotoxin-induced lung injury may be partly mediated by the modulation of neuropeptides and CS content in vivo