论文部分内容阅读
目的探讨XIAP在儿童非霍奇金淋巴瘤（NHL）发生发展中的作用和可能机制。方法采用免疫组织化学 S-P法对45例儿童 NHL和12例淋巴结反应增生组织中XIAP的表达进行检测。结果 XIAP在淋巴结反应增生组织中呈低表达，在NHL组织中呈高表达，二者之间有显著性差异。45例淋巴瘤组织中，XIAP表达强度与临床分期有关，与临床分型无显著相关。结论 XIAP可能在儿童NHL的发生、发展中起重要作用，可能会作为预后不良的标志。“,”Objective Explore the functions of XIAP in children's NHL and its possible mechanisms though studying.Methods Immunohistochemical S-P method was employed to detect the expression of XIAP in 45 cases Children's NHL lymph node and 12 cases of reactive hyperplasia of lymph node specimens.Results Low XIAP expression was found in reactive hyperplasia of lymph node, whereas high expression found in NHL lymph node. The dif erence was significant . In 45 cases Children's NHL lymph node, the expression of XIAP was related to the clinical stage, and was irrelevant to immune phenotype of Children's NHL.Conclusion XIAP may be closely related with the occurrence of tumors and involved in children's NHL development. XIAP may be used as one of the indicators to judge the condition and the prognosis.