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目的:分析成人继发孔型房间隔缺损(ASD)封堵术后左房形态及功能变化与年龄的关系。方法:49例成人ASD患者依据年龄分成二组:,<40岁组23(男13,女10)例,年龄20～38(31±12)岁。≥40岁组26(男9,女17)例,年龄40～72(49±14)岁。均于术前、术后2 d、1月、3月、6月行经胸超声心动图(TTE)检查,测量左房左右径及左房相关容积。结果:<40岁组ASD患者封堵术后3月,左房左右径较术前减小(P<0.05),≥40岁组ASD患者封堵术后6月左房左右径较术前减小(P<0.05);<40岁组ASD患者封堵术后2 d左房储蓄容积较术前减小(P<0.05),≥40岁组ASD患者封堵术后6月较术前明显减小(P<0.05);<40岁组ASD患者封堵术后3月左房被动排空容积较术前明显缩小(P<0.05),≥40岁组ASD患者封堵术后6个月时才明显缩小(P<0.01);<40岁组ASD患者封堵术后1月,LAEF较术前明显增加(P<0.01),≥40岁组ASD患者封堵术后3个月,LAEF较术前明显增加(P<0.01)。结论:≥40岁ASD患者封堵术后左房形态及功能恢复较慢。
OBJECTIVE: To analyze the relationship between left atria morphological and functional changes and age after occlusion of adult patients with atrial septal defect (ASD). METHODS: Forty-nine adult ASD patients were divided into two groups according to their age: 23 (13 males and 10 females) under the age of 40 years and 20 to 38 years (31 ± 12 years). The group of ≥40 years old 26 (9 males and 17 females), aged 40 to 72 (49 ± 14) years old. All patients underwent thoracic echocardiography (TTE) before surgery, 2 days after surgery, 1 month, 3 months and 6 months after operation. Left atrium dimensions and left atrium dimensions were measured. Results: In the 40-year-old ASD group, the left and right left and right diameters of the patients with ASD were significantly decreased at 3 months after closure (P <0.05) (P <0.05). In the 40-year-old ASD group, the volume of left atrium was decreased 2 days after the occlusion of ASD (P <0.05), and the ASD in 40-year-old group was significantly higher than that before operation (P <0.05). In the 40-year-old ASD patients, the passive left ventricular volume was significantly reduced in 3 months after occlusion of the left atrium (P <0.05), and the ASD in the 40-year-old group was 6 months (P <0.01). In the group of 40-year-old patients with ASD, the LAEF was significantly increased at 1 month after closure (P <0.01) Compared with preoperative significantly increased (P <0.01). Conclusions: Left atrium morphology and function recover more slowly in patients with ASD over 40 years old after occlusion.