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本实验复制２４只杂种犬心肌缺血再灌注损伤病理模型，应用与生理盐水、丹参对比的方法观察通脉灵对血液动力学及心功能的影响。结果表明，通脉灵小剂量组（ＴＭ１Ｇ）、通脉灵大剂量组（ＴＭ２Ｇ）和丹参对照组（ＤＳＧ）的心输出量（ＣＯ），心脏指数（ＣＩ），心搏指数（ＳＩ）、左室内压峰值（ＬＶＳＰ）及左室内压最大变化速率（±ｄｐ／ｄｔｍｓｘ）均明显高于生理盐水对照组（ＮＳＧ）。本实验证明，通脉灵主要是通过保护心肌舒缩功能改善血液动力学指标进而防止缺血再灌注时心功能不全的发生。
In this experiment, the pathological model of myocardial ischemia-reperfusion injury was reproduced in 24 hybrid dogs. The effect of Tongmailing on hemodynamics and cardiac function was observed by comparing with normal saline and salvia miltiorrhiza. The results showed that the cardiac output (CO), cardiac index (CI), heart rate index (SI), Tongmailing low-dose group (TM1G), Tongmailing high-dose group (TM2G) and Danshen control group (DSG), The left ventricular peak pressure (LVSP) and the maximum rate of left ventricular pressure (±dp/dtmsx) were significantly higher than that of the saline control group (NSG). This experiment proves that Tongmailing is mainly used to protect the myocardial contraction and contraction function to improve the hemodynamic index and prevent the occurrence of cardiac insufficiency during ischemia and reperfusion.