论文部分内容阅读
本文报道了 18个 (E) 4 芳酰氧基苯基丙烯酸类衍生物的设计与合成。其中 17个化合物未见文献报道。所有目标物的化学结构经元素分析、红外光谱和核磁共振氢谱确证。初步体外抑癌试验结果表明 ,在 0 3μmol·L- 1 浓度下化合物 3e、3f、3g、3h、3k、4h和 4j对小鼠艾氏腹水癌 (EAC)呈现显著抑制作用。
This paper reports the design and synthesis of 18 (E) 4 aroyloxy phenyl acrylic derivatives. Among them, 17 compounds have not been reported in the literature. The chemical structure of all the targets was confirmed by elemental analysis, IR and 1H-NMR. The preliminary in vitro tumor suppression test showed that the compounds 3e, 3f, 3g, 3h, 3k, 4h and 4j exhibited significant inhibitory effects on Ehrlich ascites carcinoma (EAC) at a concentration of 0 3 μmol·L -1.