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为了综合传统不可逆电穿孔和ns脉冲的特点,充分发挥脉冲电场非热治疗肿瘤的优势,将高频ns脉冲串引入到消融肿瘤组织的应用中,并研究了此高频ns脉冲串在生物组织中产生的热效应。通过多参数有限元方法对施加1对针电极的肝脏和肿瘤组织的温度以及热损伤进行了仿真,施加的电压范围为1~4 k V,脉冲宽度范围为50~500 ns,重复频率介于100 k Hz~1 MHz之间,脉冲串长度为100μs,脉冲串的重复频率为1 Hz。使用Pennes生物传热方程计算电热耦合下的温度,并根据Arrhenius公式计算热损伤。结果表明:肿瘤在单个脉冲串作用下在100μs时刻达到的最高温度为49.26℃;在1 s时刻最高温度为40.4℃,经过1 s时刻之后热损伤的累积程度只有0.001 6,不会造成热损伤;通过参数拟合,可以得到任意参数下的组织温度以及热损伤。研究结果可为将来的实验研究提供参数选择的理论依据。
In order to synthesize the characteristics of traditional irreversible electroporation and ns pulse and give full play to the advantage of non-thermal treatment of tumor by pulse electric field, the introduction of high-frequency ns pulse train into the application of ablating tumor tissue and the study of the high-frequency ns pulse train in biological tissue In the thermal effect. The temperature and thermal damage of the liver and tumor tissue implanted with a pair of needle electrodes were simulated by a multi-parameter finite element method using a voltage range of 1 to 4 kV and a pulse width in the range of 50 to 500 ns with a repetition rate of between Between 100 k Hz and 1 MHz, the burst length is 100 μs and the burst repetition frequency is 1 Hz. The temperature under the electrothermal coupling was calculated using the Pennes bioheat equation and the thermal damage was calculated from the Arrhenius equation. The results showed that the maximum temperature reached by the tumor in a single pulse train was 49.26 ℃ at 100μs, the maximum temperature was 40.4 ℃ at 1 s, and the cumulative degree of thermal damage was only 0.001 6 after 1 s, which did not cause thermal damage Through the parameter fitting, the tissue temperature and the thermal damage under any parameters can be obtained. The results of the research can provide the theoretical basis for the future experimental research.