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目的 最近在输血后肝炎病人中发现了一种新型肝炎病毒 ,并命名为输血传播的病毒即TTV。我们在一次经肠道传播的非甲非戊型肝炎暴发流行的病人粪便和血清中也检测到了这一病毒。本文旨在于回顾这种新型病毒的流行病学特征和实验感染。方法 主要收集我们的资料 ,并参照世界各地有关论著。结果 在一次经肠道传播的非甲非戊型肝炎的暴发流行中 ,从 381名学生 (6 0 7% )的血清和粪便标本中检测到TTV病毒的片段 ,该职校中无症状携带者的血清阳性率为 32 1% ,而粪便阳性率为 2 4 6 % ,提示有潜在的传染源存在。来自中国北方与南方的两个偏远农村人群流行病学调查 ,其阳性率分别为 9 2 %和 10 6 % ,表明中国是TTV感染的地方性流行区。我们用TTV阳性肝炎病人的粪便滤过液分别经灌胃和静脉接种两种途径成功地使两组恒河猴 (每组 3只 )感染了TTV ,并对其中两只恒河猴进行了研究 ,分别在它们的肝、脾、小肠和结肠组织中检测到TTV ,而单链的复制中间体 ,仅仅在肝和小肠中检测到。结论 这种无包膜的DNA病毒可能经血液和肠道途径传播 ,根据其广泛分布和高的流行率 ,我们推测肠道传播是更为重要的
Objective Recently, a new type of hepatitis virus was found in patients with post-transfusion hepatitis and was named as transfusion-transmitted virus (TTV). We also detected the virus in the excrement and serum of a pandemic non-A, non-hepatitis E-outbreak patient. This article aims to review the epidemiology and experimental infection of this new virus. The method mainly collects our information and refers to the relevant treatises around the world. Results In an outbreak of enteric-coated non-hepatitis E non-hepatitis E, fragments of the TTV virus were detected in serum and stool specimens from 381 students (60.7%) who were asymptomatic carriers The seroprevalence was 32 1%, while the stool positive rate was 24.6%, suggesting a potential source of infection. The epidemiological survey of two remote rural populations from northern and southern China showed a positive rate of 92% and 106% respectively, indicating that China is endemic to TTV infection. Two groups of Rhesus macaques (3 in each group) were successfully infected with TTV by fecal filtrate from TTV-positive hepatitis patients by gavage and intravenous inoculation, respectively, and two of the rhesus monkeys were studied TTV was detected in their liver, spleen, small intestine and colon tissues, respectively, whereas single-stranded replication intermediates were detected only in the liver and small intestine. Conclusions The non-enveloped DNA virus may be transmitted by the blood and gut pathways, and we speculate that gut spread is even more important, given its wide distribution and high prevalence