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目的观察大剂量GIK治疗重症肝炎对Th2类细胞因子及临床各项肝功能指标的影响。方法 50例患者随机分为两组,对照组常规治疗。试验组加用大剂量极化液治疗。治疗前后采用ELESA法检测TNF-α、IL-1,IL-4、IL-6和IL-10的水平,同时查肝功能等常规检查。结果应用大剂量极化液治疗重症肝炎后患者血清ALT、AST、总胆红素、TNF-α、IL-1水平均较治疗前明显降低,而IL-10水平则升高,其变化幅度明显大与对照组,两组比较具有统计学意义。结论大剂量的GIK治疗重症肝炎疗效优于常规疗法,机制可能与调节Th2类细胞因子有关。
Objective To observe the effects of high-dose GIK treatment of severe hepatitis on Th2 cytokines and clinical indicators of liver function. Methods 50 patients were randomly divided into two groups, the control group conventional treatment. The experimental group plus a large dose of polarized liquid treatment. ELESA was used to detect the levels of TNF-α, IL-1, IL-4, IL-6 and IL-10 before and after treatment. Results Serum levels of ALT, AST, total bilirubin, TNF-α and IL-1 in patients with severe hepatitis were significantly lower than those before treatment, while the levels of IL-10 were significantly increased Large and control group, the two groups were statistically significant. Conclusions High-dose GIK treatment of severe hepatitis is more effective than conventional therapy, and the mechanism may be related to the regulation of Th2 cytokines.