论文部分内容阅读
[目的]观察早期应用倍他乐克对于急性心肌梗死(AMI)患者的临床效果及对左心室收缩功能的影响。[方法]2007年6月～2010年6月,122例AMI患者随机分为两组,对照组61例仅采用常规治疗,观察组61例在常规治疗基础上早期应用倍他乐克治疗,比较观察两组的临床效果和左心室收缩功能指标的变化。[结果]观察组的心衰加重率、心源性猝死率和住院总死亡率均明显低于对照组,两组比较差异有统计学意义(P﹤0.05)。观察组治疗后LVEDd水平明显下降,LVFS和LVEF水平明显升高,与治疗前差异有统计学意义(P﹤0.05);而对照组治疗前后比较,差异无统计学意义(P﹥0.05)。观察组治疗后LVEDd、LVFS和LVEF水平与同期对照差异有统计学意义(P﹤0.05)。[结论]早期应用倍他乐克对于AMI患者能够明显降低心衰加重率、心源性猝死率和住院总死亡率,并且能明显改善左心室收缩功能,值得临床推广应用。
[Objective] To observe the clinical effect of early application of metoprolol in patients with acute myocardial infarction (AMI) and its effect on left ventricular systolic function. [Method] From June 2007 to June 2010, 122 patients with AMI were randomly divided into two groups. The control group, 61 cases, were treated with conventional therapy only. The observation group received 61 cases of early metoprolol treatment on the basis of routine treatment The clinical effects and changes of left ventricular systolic function were observed in both groups. [Results] The rate of heart failure, sudden cardiac death and total hospital mortality in the observation group were significantly lower than those in the control group. There was significant difference between the two groups (P <0.05). After treatment, the LVEDd level in the observation group decreased significantly, while the LVFS and LVEF levels increased significantly (P <0.05), but there was no significant difference in the control group before and after treatment (P> 0.05). The LVEDd, LVFS and LVEF levels in the observation group were significantly different from those in the same period (P <0.05). [Conclusion] The early application of Betaloc can significantly reduce the worsening rate of heart failure, sudden cardiac death and hospitalized total mortality in patients with AMI, and can significantly improve the left ventricular systolic function, which is worthy of clinical application.