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英国儿童肿瘤研究组(UKCCSG)对恶性生殖细胞肿瘤的研究,建立了调查、分期和治疗儿童肿瘤的标准记录,研究新药联合治疗的效果以及连续测定血清AFP和HCG的价值。本文报告1979～1987年,126例0至16岁患恶性生殖细胞肿瘤儿童的治疗结果,其中71例男孩、55例女孩。在1988年分析了126例儿童原发肿瘤的部位和分期。卵巢恶性肿瘤共29例,按FIGO分期,Ⅰ期7例、Ⅱ期3例、Ⅲ期15例和Ⅳ期4例;骶尾部肿瘤21例,其中16例为女性。卵巢恶性生殖细胞肿瘤主要发生在10岁左右。126例中21例(17%)伴有先天性畸形,其中3例为XY性腺发育不良。 123例测血AFP值,有115例升高,77例测血
The British Children’s Oncology Group (UKCCSG) study of malignant germ cell tumors established a standard record for investigating, staging and treating pediatric tumors, examining the efficacy of new drug combinations and the value of continuous measurement of serum AFP and HCG. This article reports the results of 126 children aged 0 to 16 years with malignant germ cell tumors from 1979 to 1987, of which 71 were boys and 55 were girls. In 1988, 126 primary tumors of the child were analyzed for location and staging. A total of 29 cases of ovarian cancer, according to FIGO staging, Ⅰ in 7 cases, Ⅱ in 3 cases, Ⅲ in 15 cases and Ⅳ in 4 cases; 21 cases of sacrococcygeal tumors, of which 16 were female. Malignant ovarian germ cell tumors occur mainly in the 10-year-old. Among 126 cases, 21 cases (17%) had congenital malformations, of which 3 cases were XY gonadal dysplasia. 123 cases of blood test AFP value, 115 cases were elevated, 77 cases of blood