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目的：探讨Ⅱ型糖尿病患者红细胞膜Ｎａ＋，Ｋ＋—三磷酸腺苷（ＡＴＰ）酶和Ｃａ２＋－ＡＴＰ酶活性改变参与糖尿病性血管病的可能机制。方法：测定５０例正常人、３６例无血管病和４１例有血管病的Ⅱ型糖尿病患者的血压、空腹血糖、平均红细胞容积、平均血小板容积、红细胞膜Ｎａ＋，Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性。统计方法用ｔ检验和直线相关分析。结果：无血管病的Ⅱ型糖尿病患者血压显著高于正常人（Ｐ＜０．０１），红细胞膜Ｎａ＋，Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性均显著低于正常人（Ｐ＜０．０１）。有血管病患者血压、平均红细胞容积和平均血小板容积均明显高于无血管病患者及正常人（Ｐ＜０．０１），红细胞膜Ｎａ＋，Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性明显低于无血管病患者及正常人（Ｐ＜０．０１～Ｐ＜０．０５）。Ⅱ型糖尿病患者红细胞膜Ｎａ＋，Ｋ＋－ＡＴＰ酶活性和平均红细胞容积或平均血小板容积均呈负相关（ｒ＝－０．２３，－０．２９，Ｐ＜０．０５）。收缩压和Ｃａ２＋－ＡＴＰ酶活性呈负相关（ｒ＝－０．２４，Ｐ＜０．０５），和病程呈正相关（ｒ＝０．２４，Ｐ＜０．０５）。舒张压和病程呈正相关（Ｐ＜０．０５）。结论：糖尿病性血管病的发生发展和?
Objective: To investigate the possible mechanism involved in the alteration of erythrocyte membrane Na +, K + -ATPase and Ca2 + -ATPase activity in type 2 diabetic patients involved in diabetic vascular disease. Methods: Blood pressure, fasting blood glucose, mean corpuscular volume, mean platelet volume, erythrocyte membrane Na +, K + -ATPase and Ca2 + -ATP were measured in 50 normal subjects, 36 non-vascular patients and 41 diabetic patients with type 2 diabetes mellitus Enzyme activity. Statistical methods using t test and linear correlation analysis. Results: The blood pressure of patients with type 2 diabetes without vascular disease was significantly higher than that of normal people (P <0.01). The activities of Na +, K + -ATPase and Ca2 + -ATPase in erythrocytes were significantly lower than those in normal people (P <0.01) ). The blood pressure, mean corpuscular volume and mean platelet volume of patients with vascular disease were significantly higher than those without vascular disease and normal subjects (P <0.01). The activities of Na +, K + -ATPase and Ca2 + -ATPase in erythrocytes were significantly lower than those without vascular disease Vascular disease patients and normal subjects (P <0.01 ~ P <0.05). Erythrocyte membrane Na +, K + -ATPase activity was negatively correlated with mean erythrocyte volume or mean platelet volume in type 2 diabetic patients (r = -0.23, -0.29, P <0.05). Systolic blood pressure and Ca2 + -ATPase activity was negatively correlated (r = -0.24, P <0.05), and the duration was positively correlated (r = 0.24, P <0.05). Diastolic pressure and duration were positively correlated (P <0.05). Conclusion: The occurrence and development of diabetic vascular disease and?