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工布乌头(Aconitum kongboense Lauener var. villogam W. T. Wang)系毛茛科植物,产于西藏,泡酒外搽治跌打损伤、毒虫咬伤,其化学成分未见报道。我们从其根中分得一生物碱,称为AK-1,其分离鉴定如下: 取原植物200g根粉,用0.05N HCl渗滤,至渗出液对改良的Dragendorff试剂反应呈阴性。共收集滤液2900ml,使其通过聚苯乙烯磺酸H型离子交换树脂(含水90%)柱,流出液应无生物碱反应。常法操作,用去离子水洗涤、凉干、称重,加10%氨水135ml碱化后,置回
Aconitum kongboense Lauener var. villogam W. T. Wang is a family of Ranunculaceae plants, produced in Tibet and treated with soaked wine. It has not been reported on its chemical composition. We isolated an alkaloid called AK-1 from its roots. The isolates were identified as follows: 200 g root powder of the original plant was taken and diafiltered with 0.05 N HCl until the exudate reacted negatively to the modified Dragendorff reagent. A total of 2900 ml of the filtrate was collected and passed through a polystyrene sulfonic acid H-type ion exchange resin (90% aqueous) column. The effluent should have no alkaloid reaction. Normal operation, wash with deionized water, dry, weigh, add 10% ammonia 135ml alkalinity, put back