长期大剂量左旋多巴治疗帕金森氏综合征,仅能维持3～4年的最适当的疗效,此后多再无明显疗效,副作用多,且难以处理,此时可停用左旋多巴,直至绝对需要时再开始用最小剂量治疗。小剂量隔日治疗,用药日及不用药日皆有稳定的临床效果,因为疗效不依赖血浆多巴含量,而靠中枢机理。 Long-term high-dose levodopa treatment of Parkinson\'s disease, can only maintain the most appropriate curative effect of 3 to 4 years, then no more significant effect, side effects and more difficult to handle, then disable levodopa, until Absolutely need to start with the minimum dose treatment. Small doses of every other day treatment, medication day and no medication all have a stable clinical effect, because the effect does not depend on plasma dopamine content, but by the central mechanism.