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帕金森病是一种常见的神经系统退行性疾病,内质网应激在帕金森病发病过程中具有重要的作用。瞬时受体电位阳离子通道1(transient receptor potential channel 1,TRPC1)是非选择性的阳离子通道,主要位于细胞膜上,可以调节Ca2+的内流和抑制内质网应激所致的神经元凋亡。Ca2+是细胞内重要的第二信使,其浓度的稳定对维持细胞的功能起着重要作用。内质网是细胞内Ca2+储存的重要细胞器。因此,TRPC1和Ca2+在帕金森病中起着重要作用。综述了TRPC1和Ca2+与帕金森病内质网应激的相关进展。
Parkinson’s disease is a common neurodegenerative disease. Endoplasmic reticulum stress plays an important role in the pathogenesis of Parkinson’s disease. Transient receptor potential channel 1 (TRPC1) is a non-selective cation channel mainly located in the cell membrane, which can regulate the influx of Ca2 + and inhibit neuronal apoptosis induced by endoplasmic reticulum stress. Ca2 + is an important second messenger in cells. The stability of its concentration plays an important role in maintaining the function of cells. Endoplasmic reticulum is an important organelle for intracellular Ca2 + storage. Therefore, TRPC1 and Ca2 + play an important role in Parkinson’s disease. The progress of TRPC1 and Ca2 + in the endoplasmic reticulum stress in Parkinson’s disease was reviewed.