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目的探讨长方案中使用长效和短效曲普瑞林(triptorelin)降调节对体外受精结局的影响。方法回顾性分析曲普瑞林长方案(985例)在控制性超排卵中应用的资料,其中短效曲普瑞林降调节的为A组(435例),长效曲普瑞林降调节的为B组(550例)。结果 A组临床妊娠率65.36%,B组为66.29%,两组差异无统计学意义(P>0.05)。两组促性腺激素(gonadotrophin,Gn)用量、获卵数、受精率、卵裂率等的差异亦无统计学意义(P>0.05)。B组因孕酮(P)升高周期取消率为3.45%,A组则为1.61%,差异有统计学意义(P<0.05)。结论长方案降调节中曲普瑞林的不同剂型对体外受精结局没有显著影响,但长效曲普瑞林降调节中孕酮水平有升高趋势。
Objective To investigate the effect of long-term and short-term triptorelin down-regulation on in vitro fertilization outcomes in long-term regimens. Methods The retrospective analysis of triptorelin long-term program (985 cases) in the control of superovulation in the application of information, including short-acting triptorelin down regulation in the A group (435 cases), long-acting triptorelin down regulation For the B group (550 cases). Results The clinical pregnancy rate in group A was 65.36%, while that in group B was 66.29%. There was no significant difference between the two groups (P> 0.05). There was no significant difference in the amount of gonadotrophin (Gn), number of oocytes retrieved, fertilization rate and cleavage rate between the two groups (P> 0.05). In group B, the cancellation rate of elevated progesterone (P) was 3.45% in group A and 1.61% in group A, with significant difference (P <0.05). Conclusion Different dosage forms of triptorelin in long-term regimen have no significant effect on in vitro fertilization outcome, but progesterone level in long-acting triptorelin down regulation has an increasing trend.