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例1,女,51岁,因高血压病自1988年来一直用心痛定治疗,血压控制较满意,但于1990年底血压又不稳定,常在24.0/13.3Pa左右,故加服甲巯丙脯酸25mg,1次/日。加药2周后出现咳嗽,始为单声干咳,后转为阵发性干咳,每日数次至10余次,每次持续1～2分钟,夜间为甚,嗅及油烟味诱发剧咳。经服止咳消炎药不能缓解,血象及胸诱检查正常。后考虑为甲巯丙脯酸所致而停服,停药第一天剧咳次数减少,第二天咳嗽明显减轻,第三天咳嗽完全消失。例2,男,59岁,因高血压病于1990年12月21日用甲巯丙脯酸治疗,25mg,2次/日,2周后改为25mg,3次/日,血压控制满意。1991年3月初开始出现咳嗽,夜间阵发性剧烈干咳、每次持续2
Case 1, female, 51 years old, since 1988 has been painkillers for hypertension treatment, blood pressure control is more satisfactory, but in the end of 1990 the blood pressure is not stable, often around 24.0 / 13.3Pa, so add a captopril Acid 25mg, 1 time / day. Cough 2 weeks after dosing, the beginning of the single dry cough, paroxysmal dry cough after the turn, several times a day to more than 10 times, each lasting 1 to 2 minutes, even worse at night, sniffing and smoke smell induced cough. Anti-cough anti-inflammatory drugs can not be relieved, blood and thoracic examination normal. Considered to be due to captopril due to stop taking, the first day of withdrawal of cough reduced the number of cough the next day significantly reduced the cough on the third day completely disappeared. Example 2, male, 59 years old, due to hypertension in December 21, 1990 with captopril treatment, 25mg, 2 times / day, 2 weeks later changed to 25mg, 3 times / day, blood pressure control. Cough started to appear in early March 1991 and severe paroxysmal nocturnal cough occurred at night, each time lasting 2