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噻嗪类利尿药及其衍生物都有作用机理不同的两种药理作用:利尿作用是药物对于肾小管的作用;降压作用是药物对于微动脉血管平滑肌的作用。一、噻嗪类利尿药的利尿作用及其机理 1.排钠、氯及水的作用:该药直接作用于肾小管,抑制其对钠、氯和水的再吸收,这一点,已从Laveneder把氯噻嗪直接注入肾动脉所得的结果中得到证实:注射氯噻嗪侧的肾脏可看到有钠、氯和水的排泄。氯噻嗪本身也在近曲小管排泄。羧苯磺胺可
Thiazide diuretics and their derivatives have two different pharmacological effects of different pharmacological effects: diuretic effect is the role of drugs on the tubules; antihypertensive effect is the role of drugs on micro-vascular smooth muscle. First, the diuretic effect of thiazide diuretics and its mechanism 1. Row of sodium, chlorine and water role: The drug directly on the tubules, inhibition of sodium, chlorine and water resorption, which has been from Laveneder The results obtained by injection of chlorothiazide directly into the renal arteries have been confirmed by the excretion of sodium, chloride and water by the kidneys injected on the chlorothiazide side. Chlorothiazide itself is also excreted in the proximal tubule. Carbosulfan can be