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目的 探讨中性粒细胞明胶酶相关脂质运载蛋白(NGAL)对住院心力衰竭(简称心衰)患者肾功能的预测价值.方法 连续入选396例因心衰住院的患者,根据慢性肾脏病流行病学合作研究公式(CKD-EPI)计算肾小球滤过率(eGFR),将入选患者分为心肾综合征(CRS)组[eGFR＜60 ml/(min·1.73 m2),凡=97]和非CRS组[eGFR≥60 ml/(min·1.73 m2),n=299],测定两组患者NGAL、N末端B型利钠肽原(NT-proBNP)、肌酐、尿素氮等指标浓度.结果 CRS组NGAL、NT-proBNP水平均明显高于非CRS组(P＜0.01).NGAL与NT-ProBNP、肌酐、尿素氮呈正相关(r=0.194、0.527、0.433,P＜0.01).NGAL及NT-ProBNP、尿素氮预测住院心衰患者肾功能恶化ROC曲线下面积分别为0.863、0.681、0.828(P＜0.01).结论 血浆NGAL对住院心衰患者肾功能恶化具有独立预测的作用.“,”Objective To explore the prognostic value of baseline plasma neutrophil gelatinase-associated the lipocalin(NGAL) for worsening renal function in heart failure (HF).Methods We consecutively enrolled 396 patients hospitalized with HF and used chronic kidney disease epidemiology collaboration (CKD-EPI) formula to calculate estimated glomerular filtration rate (eGFR).All patients were divided into 2 groups:cardiorenal syndrome (CRS) group [eGFR ＜ 60 ml/(min · 1.73 m2),n =97] and non-CRS group [eGFR ≥ 60 ml/(min · 1.73 m2),n =299],indicators measuring the concentration of NGAL two groups of patients,N-terminal pro-brain natriuretic peptide (NT-proBNP),creatinine,serum urea nitrogen (BUN).Results In correlation analysis,r value between NGAL and NT-proBNP,creatine,BUN was 0.194,0.527,and 0.433,respectively (P ＜0.01).The area under the receiver operating characteristic (ROC) curve of NGAL,NT-proBNP,BUN to evaluate worsening renal function was 0.863,0.681,and 0.828,respectively (P ＜0.01).Conclusions Plasma NGAL was an independent worsening renal function predictor for hospitalized patients with heart failure.