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对疗效较低的晚期颈部转移癌使用既能改善空间线量分布,又能改善时间线量分配的不均等分割加速放疗,期望缩短疗程,提高疗效。本文对1990年1月～8月收治的42例晚期颈部转移癌采用大剂量小野与小剂量大野交替进行的不均等分割放疗,与同期均等分割放疗41例作为对照。结果:转移淋巴结消退率不均等组(71.0％)高于均等组(48.8％),P<0.05,差异显著。放疗后3年随访,颈部无瘤生存率不均等组高于均等组(66.7％与33.3％),P>0.05,无显著差异。1、2、3年生存率不均等组为73.8％、59.5％、42.9％,均等组为51.2％、36.6％、22.0％,差异显著(P<0.05)。放疗付反应两组相近,无显著差异。结论:不均等分割加速放疗与均等分割放疗比较可以缩短疗程1.5周,提高了放射治疗效果。
The use of advanced cervical metastases with lower curative effect can not only improve the spatial line quantity distribution, but also improve the time-line volume distribution of unequal segmentation accelerating radiotherapy. It is expected to shorten the course of treatment and improve the curative effect. In this paper, 42 patients with advanced cervical metastases admitted from January to August in 1990 were treated with unequal split radiotherapy alternating with large-dose Ono and small-dose Ono, and compared with 41 patients receiving equal-fractionated radiotherapy for the same period. Results: The rate of dissociation of metastatic lymph nodes was significantly higher in the unequal group (71.0%) than in the equal group (48.8%), P<0.05. After 3 years of follow-up after radiotherapy, the non-tumor-free survival rate in the neck was higher than that in the equal group (66.7% and 33.3%), P>0.05, and there was no significant difference. The 1-, 2-, and 3-year survival rates were 73.8%, 59.5%, and 42.9% in the unequal group, and 51.2%, 36.6%, and 22.0% in the equal group, with significant differences (P<0.05). Radiotherapy to respond to the two groups was similar, with no significant difference. Conclusion: Compared with equal split radiotherapy, unequal segmented accelerated radiotherapy can shorten the course of treatment by 1.5 weeks and improve the effect of radiotherapy.