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取老年记忆减退组 (简称减退组 )、老年记忆正常组 (简称正常组 )和青年组大鼠内侧隔核进行透射电镜观察。证明 :减退组内侧隔核中突触数密度较青年组和正常组分别下降了 45 .2 7%和 44.16% ( P<0 .0 1) ;突触连接带平均面积 :减退组较青年组显著增加 ( P<0 .0 5 ) ;突触连接带面密度 :减退组较青年组和正常组分别下降了 3 5 .2 9和 3 3 .3 3 ( P<0 .0 1) ;突触的体密度 :减退组较青年组和正常组分别下降了 46.98和 49.68 ( P<0 .0 1)。统计结果表明 :受试大鼠的逃避潜伏期与突触数密度、突触连接带面密度、体密度呈明显负相关 ( r=-0 .8943 ,P<0 .0 1;r=-0 .80 0 7,P<0 .0 1;r=-0 .90 17,P<0 .0 1) ;与突触连接带平均面积呈显著正相关 ( r=0 .62 73 ,P<0 .0 5 )。还证明减退组大鼠含线粒体的突触百分比、突触前体内突触小泡数都有大幅度下降 ;正常组的含线粒体突触的百分比、突触小泡数较青年组也有减少。本研究结果提示 :减退组大鼠内侧隔核突触发生退行性变 ,此改变可能是老年性记忆减退的突触学基础
The medial septal nucleus of the aged memory impairment group (referred to as the decline group), the aged memory normal group (normal group) and the young group were observed by transmission electron microscopy. It was demonstrated that the number of synaptic densities in medial septal nucleus decreased by 45.27% and 44.16% (P <0.01), respectively. The mean area of synaptic connections decreased in the subdural group compared with the young group (P <0.05). The synaptic densities in syndesmotic zone decreased by 35.29% and 33.3% (P <0.01), respectively, compared with the young group and the normal group ; Body density of synapses: decreased group than the young group and the normal group decreased by 46.98 and 49.68 (P <0.01). The statistical results showed that the escape latency of test rats was negatively correlated with synaptic number density, synaptic junction area density and body density (r = -0.8943, P <0.01; r = -0. 80 0 7, P <0 01; r = -0. 90 17, P 0 01). There was a significant positive correlation with the mean area of synaptic junction (r = 0.62 73, P <0. 0 5). It was also demonstrated that the percentage of synapses containing mitochondria and the number of synaptic vesicles in the presynaptic decreased significantly in the rats in the subdued group. The percentage of mitochondrial synapses and the number of synaptic vesicles in the normal group were also decreased compared with those in the young group. The results of this study suggest that the synaptic degeneration of the medial septal nucleus in the hypoglossal group may be the synaptic basis of senile dementia