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以舒林酸片溶出试验为例,探讨了不同方法(简易线性回归法、加权线性回归法、非线性拟合法)求算WEIBULL分布函数的差异,结果表明,国产与进口舒林酸片的溶出参数无显著差异;比较不同算法表明,采用非线性拟合法处理溶出数据较简易线性回归法、加权线性回归法更为适宜。
Taking the dissolution test of sulindac tablets as an example, the differences of WEIBULL distribution functions by different methods (simple linear regression, weighted linear regression and non-linear fitting) were discussed. The results showed that dissolution of domestic and imported sulindac tablets There was no significant difference between the two parameters. Comparing different algorithms showed that it was more suitable to use the nonlinear fitting method to process the dissolution data than the simple linear regression method and the weighted linear regression method.